Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural rheology of a model ointment

L E Pena1, B L Lee, J F Stearns

  • 1Drug Delivery R&D--Specialty Products, Upjohn Company, Kalamazoo, Michigan 49007.

Pharmaceutical Research
|June 1, 1994
PubMed
Summary

This study reveals how ointment structure changes with temperature, showing microcrystalline wax reinforces white petrolatum and mineral oil networks. Understanding these rheological properties is key for manufacturing processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolutionarily Conserved Sequence Features Regulate the Formation of the FG Network at the Center of the Nuclear Pore Complex.

Scientific reports·2015
Same author

MET in gastric carcinomas: comparison between protein expression and gene copy number and impact on clinical outcome.

British journal of cancer·2012
Same author

A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumour growth and angiogenesis.

British journal of cancer·2010
Same author

PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation.

Cell death and differentiation·2010
Same author

Myrna's four personalities are computerized patient management teaching aids.

Canadian Medical Association journal·2010
Same author

Prognostic implications of type and density of tumour-infiltrating lymphocytes in gastric cancer.

British journal of cancer·2008

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Ointments are complex semi-solid formulations used in topical drug delivery.
  • Understanding the rheological behavior and structural integrity of ointments is crucial for manufacturing and efficacy.

Purpose of the Study:

  • To investigate the rheological properties and structural characteristics of a model ointment.
  • To elucidate the role of individual components (white petrolatum, mineral oil, microcrystalline wax) in ointment structure.
  • To correlate thermal transitions with rheological changes and inform manufacturing processes.

Main Methods:

  • Rheological analysis (rheometry) across a temperature range (25-40°C).
  • Thermal optical analysis to identify melting transitions.
  • Microscopy to visualize structural components.
  • Formulation studies with varying component ratios.

Main Results:

  • Ointment rheology showed minimal shape change with increasing temperature, but two inflections disappeared.
  • Disappearance of rheological inflections correlated with the melting transitions of secondary structure components.
  • White petrolatum and mineral oil primarily control ointment rheology.
  • Microcrystalline wax enhances structure by integrating into the white petrolatum network.
  • Ointment network structure is a recombination of natural components in varied ratios.

Conclusions:

  • The study provides insights into the structure-property relationships of model ointments.
  • Understanding component interactions and thermal behavior is essential for optimizing ointment formulation and filling operations.
  • Rheological and thermal analyses are valuable tools for characterizing semi-solid formulations.

Related Experiment Videos