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[Hepatitis E--epidemiology and clinical aspects]

E Walter1

  • 1Medizinische Klinik B, Universitätsspital Zürich.

Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse De Medecine Praxis
|September 6, 1994
PubMed
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Hepatitis E virus (HEV) causes acute liver disease globally, with epidemics in Asia. Diagnosis relies on detecting anti-HEV antibodies, and severe cases are more frequent than with Hepatitis A.

Area of Science:

  • Virology
  • Hepatology
  • Infectious Diseases

Context:

  • Hepatitis E virus (HEV) is a globally distributed RNA virus.
  • Large-scale epidemics of HEV have been documented in Asia.
  • Sporadic cases of HEV infection occur, with few diagnosed in Western countries.

Purpose:

  • To describe the characteristics of Hepatitis E virus (HEV) infection.
  • To outline the global distribution and clinical presentation of HEV.
  • To detail the diagnostic methods for HEV infection.

Summary:

  • HEV infection presents as an acute, self-limiting hepatitis, similar to Hepatitis A but with a higher incidence of severe and fulminant courses.
  • While chronic liver disease or persistent viremia are not observed, diagnosis is confirmed by detecting anti-HEV antibodies.

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  • The virus has a worldwide distribution, with significant epidemic activity in the Indian subcontinent, Central Asia, and Southeast Asia.

    • Impact:

    • Provides a comprehensive overview of HEV epidemiology and clinical features.
    • Highlights the diagnostic approach for HEV infection.
    • Informs public health strategies for managing HEV outbreaks and sporadic cases.