Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Unconventional transmissible agents or prions]

D Dormont1

  • 1Laboratoire de neuropathologie expérimentale et neurovirologie, CRSSA/CEA, DSV/DPTE, Fontenay-aux-Roses.

La Revue Du Praticien
|April 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRI features of intra-axial histiocytic brain mass lesions.

Clinical radiology·2020
Same author

Are Gadolinium-Enhanced MR Sequences Needed in Simultaneous <sup>18</sup>F-FDG-PET/MRI for Tumor Delineation in Head and Neck Cancer?

AJNR. American journal of neuroradiology·2020
Same author

Subdural brain metastasis of lung adenocarcinoma on arterial spin labeling (ASL) MRI.

Diagnostic and interventional imaging·2019
Same author

MR angiography of reversible cerebral vasoconstriction syndrome.

Diagnostic and interventional imaging·2018
Same author

Progressive white-matter demyelination in delayed CO poisoning encephalopathy.

Journal of neuroradiology = Journal de neuroradiologie·2017
Same author

Characterization of Skull Base Lesions Using Pseudo-Continuous Arterial Spin Labeling.

Clinical neuroradiology·2017
Same journal

[Prolonged fever].

La Revue du praticien·2026
Same journal

[Lower gastrointestinal bleeding].

La Revue du praticien·2026
Same journal

[Management of antiplatelet agents and oral anticoagulants in cases of gastrointestinal bleeding].

La Revue du praticien·2026
Same journal

[A history of child abuse intervention in the West].

La Revue du praticien·2026
Same journal

[Agranulocytose médicamenteuse].

La Revue du praticien·2026
Same journal

[Patient education in heart failure].

La Revue du praticien·2026
See all related articles

Prions, unconventional infectious agents, cause fatal neurodegenerative diseases. These agents resist heat and nucleic acid degradation, accumulating abnormal proteins in the brain and other organs.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Biochemistry

Context:

  • Prions cause rare, fatal neurodegenerative diseases known as transmissible subacute spongiform encephalopathies.
  • These diseases are characterized by spongiosis, gliosis, and lack of inflammation or demyelination.

Purpose:

  • To describe the unique biological and physicochemical properties of prions.
  • To explain the molecular mechanism of prion pathogenesis.
  • To highlight the distribution of prion infection in animal models.

Summary:

  • Prions are unconventional transmissible agents resistant to high temperatures and nucleic acid degradation.
  • Pathogenesis involves the accumulation of protease-resistant, misfolded host prion protein (PrP).
  • Nervous system is highly infected, with widespread organ involvement preceding clinical signs, explaining iatrogenic transmission.

Related Experiment Videos

Impact:

  • Understanding prion properties is crucial for developing diagnostic and therapeutic strategies.
  • Identifying prion distribution aids in understanding disease transmission and preventing iatrogenic spread.
  • This research contributes to the broader field of protein misfolding diseases.