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Tumor induction in mice administered neonatally with N-bis(2-hydroxypropyl)nitrosamine (BHPN)
K Fujii1, T Hayakawa, M Kikuchi
1Department of Pathology, University of Tsukuba, Ibaraki, Japan.
The Science Reports of the Research Institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku
|December 1, 1993
Abstract:
Two subcutaneous injections of N-bis(2-hydroxypropyl)nitrosamine (BHPN) to mice on day 1 and 8 induced tumors of the lung, liver, nasopharynx and pancreas, when animals were killed at the end of one year. The tumor incidences of lung were 90-100%; those of liver 60-92%; those of nasopharynx 3-13%; those of pancreas 2-3%, respectively. The average tumor nodules of lung and those of liver increased in a dose-dependent manner. Two doses of 50 mg/g body weight of BHPN induced one duct cell carcinoma and one acinar cell adenoma of pancreas in a mouse, respectively.