Related Experiment Videos
Differential regulation of RNA polymerases I, II, and III by the TBP-binding repressor Dr1
R J White1, B C Khoo, J A Inostroza
1Wellcome/CRC Institute, University of Cambridge, UK.
Science (New York, N.Y.)
|October 21, 1994
Abstract:
RNA polymerases I, II, and III each use the TATA-binding protein (TBP). Regulators that target this shared factor may therefore provide a means to coordinate the activities of the three nuclear RNA polymerases. The repressor Dr1 binds to TBP and blocks the interaction of TBP with polymerase II- and polymerase III-specific factors. This enables Dr1 to coordinately regulate transcription by RNA polymerases II and III. Under the same conditions, Dr1 does not inhibit polymerase I transcription. By selectively repressing polymerases II and III, Dr1 may shift the physiological balance of transcriptional output in favor of polymerase I.