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Reovirus-like agent (rotavirus) from lambs

M S McNulty, G M Allan, G R Pearson

    Infection and Immunity
    |December 1, 1976
    PubMed
    Summary

    Rotavirus was identified in lamb feces, showing an antigenic link to other rotaviruses. Experimental infection in lambs demonstrated viral replication but not diarrhea, offering insights into lamb rotavirus disease.

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    Area of Science:

    • Veterinary Virology
    • Gastroenterology
    • Animal Health

    Background:

    • Rotaviruses are a significant cause of diarrhea in young animals.
    • Lamb diarrhea can be caused by various pathogens, including rotaviruses.
    • Understanding lamb rotavirus is crucial for animal health management.

    Purpose of the Study:

    • To identify and characterize rotavirus in lambs with diarrhea.
    • To investigate the antigenic relationship of lamb rotavirus with other strains.
    • To determine the pathogenesis of lamb rotavirus in experimentally infected lambs.

    Main Methods:

    • Electron microscopy of fecal samples.
    • Cell culture for viral antigen synthesis.
    • Immunofluorescence for antigenic relationship determination.
    • Experimental infection of colostrum-deprived lambs.

    Main Results:

    • Rotavirus particles were visualized in the feces of diarrheic lambs.
    • Lamb rotavirus antigen was synthesized in cell culture but not serially adapted.
    • An antigenic relationship was confirmed between lamb, pig, and calf rotaviruses.
    • Experimental infection led to viral replication in the small intestine and fecal excretion, but no diarrhea.

    Conclusions:

    • Lamb rotavirus can be identified and its antigenic properties studied.
    • Experimental infection models are valuable for understanding rotavirus pathogenesis in lambs.
    • Further research is needed to elucidate the factors causing diarrhea in naturally infected lambs.

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