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Organ preservation

A M D'Alessandro1, J H Southard, R B Love

  • 1Department of Surgery, University of Wisconsin Medical School, Madison.

The Surgical Clinics of North America
|October 1, 1994
PubMed
Summary
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Clinical organ transplantation shows high graft survival rates. While current preservation methods meet needs for liver, pancreas, and kidney, advancements in heart and lung preservation are crucial for expanding donor organ availability.

Area of Science:

  • Transplantation immunology and organ preservation science.

Background:

  • Clinical transplantation outcomes are critical for patient survival.
  • Current organ preservation techniques vary in efficacy across different organs.

Purpose of the Study:

  • To evaluate current clinical transplantation results and organ preservation methods.
  • To identify areas for improvement in organ preservation for enhanced donor organ availability.

Main Methods:

  • Review of clinical transplantation data, focusing on graft survival rates.
  • Assessment of current preservation techniques for liver, pancreas, kidney, heart, and lung.

Main Results:

  • Achieved approximately 90% graft survival after 1 year for clinical transplants.
  • Current preservation meets clinical needs for liver, pancreas, and kidney.

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  • Improvements are needed for heart and lung preservation.

    • Conclusions:

    • Current preservation methods are largely adequate but require enhancement for thoracic organs.
    • Future advancements in machine perfusion hold promise for superior organ preservation and increased organ availability.