Related Experiment Video

Updated: Aug 19, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

[Current concepts of oxalate nephropathies (clinical and population studies)]

M S Ignatova, E A Kharina, O I Iaroshevskaia

    Terapevticheskii Arkhiv
    |January 1, 1994
    PubMed

    Insights

    Dysmmetabolic nephropathy (DN) in children presents nonspecific symptoms like occult blood in urine, mild proteinuria, and kidney tissue changes. Its development is linked to genetic, biochemical, and environmental factors.

    Area of Science:

    • Pediatric Nephrology
    • Urology
    • Clinical Medicine

    Background:

    • Dysmmetabolic nephropathy (DN) is an emerging health concern in pediatric populations, extending beyond urolithiasis-endemic areas.
    • Understanding the clinical and laboratory manifestations of DN is crucial for timely diagnosis and management.

    Purpose of the Study:

    • To characterize the clinical and laboratory findings in children diagnosed with dysmetabolic nephropathy.
    • To identify obligatory diagnostic symptoms and explore the multifactorial genesis of DN.

    Main Methods:

    • Clinical and laboratory examinations were conducted on 176 children across three groups: populational, hospital, and control.
    • Renal tissue biopsy and cytomembrane characterization were performed to assess pathological changes.

    Main Results:

    • Nonspecific symptoms were observed, with obligatory signs including occult blood in urine (OCC), microhematuria, and/or mild proteinuria.
    • Key findings also included cytomembrane alterations, impaired tubular function, and tubulo-interstitial changes.

    Conclusions:

    • Dysmmetabolic nephropathy in children exhibits characteristic, albeit nonspecific, clinical and laboratory features.
    • The pathogenesis of DN is multifactorial, involving genetic predisposition, biochemical abnormalities, and environmental influences.

    More Related Videos

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

    Published on: April 4, 2025

    Isolation of Primary Human Proximal Tubule Epithelial Cells and Their Use in Creating a Microphysiological Model of the Renal Proximal Tubule07:06

    Isolation of Primary Human Proximal Tubule Epithelial Cells and Their Use in Creating a Microphysiological Model of the Renal Proximal Tubule

    Published on: May 9, 2025

    Related Concept Videos

    Analysis of Population Pharmacokinetic Data01:12

    Analysis of Population Pharmacokinetic Data

    Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
    Acute Pyelonephritis II: Diagnostic Studies and Management01:28

    Acute Pyelonephritis II: Diagnostic Studies and Management

    Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
    Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

    Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

    Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
    Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

    Urinary Tract Calculi IV: Nutrition Therapy and Prevention

    Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
    Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

    Acute Kidney Injury IV: Diagnostic Studies and Prevention

    Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
    Chronic Kidney Disease II: Clinical Manifestations01:24

    Chronic Kidney Disease II: Clinical Manifestations

    Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...