[Experience with the multiple use of dialyzers]

Area of Science:

• Biomaterials Science
• Nephrology
• Medical Device Engineering

Background:

• Dialysis involves extracorporeal blood circulation, posing risks of blood element activation and biocompatibility issues.
• Capillary dialyzers with various membranes are used, and their performance upon reuse is a critical consideration.

Purpose of the Study:

• To compare the biocompatibility of capillary dialyzers during their first and second use.
• To investigate the role of membrane surface characteristics in dialyzer reuse.
• To evaluate the effectiveness of different cleaning treatments for reused dialyzers.

Main Methods:

• Assessing biocompatibility through dialysis leukopenia and complement system activation.
• Analyzing blood element interactions with dialyzer membranes.
• Utilizing electron microscopy to examine hollow fiber membrane surfaces after reuse.
• Comparing different chemical treatments for dialyzer reprocessing.

Main Results:

• Biocompatibility of dialyzers improved with reuse.
• Electron microscopy revealed a protein layer on membrane surfaces contributing to improved biocompatibility.
• Treatment with an acetic and peracetic acid mixture was more effective than other methods.
• Clinical outcomes showed positive changes with dialyzer reuse.

Conclusions:

• Reuse of capillary dialyzers enhances biocompatibility and clinical efficacy.
• Membrane protein layer formation is crucial for improved biocompatibility in reused dialyzers.
• Acetic and peracetic acid mixture is a superior reprocessing method for dialyzers.