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Updated: Aug 11, 2026

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement
Published on: January 19, 2017
Eukaryotic replication origins: control in space and time
1Department of Genetics, University of Washington, Seattle 98195.
Abstract:
Replication origins facilitate the choreography of genome duplication by acting as targets for regulatory mechanisms. Eukaryotic cells control the efficiency and the time of origin activity. In addition, origins that have been replicated are prevented from doing so twice in the same cell cycle. In this review we will examine the mechanisms that may be used to control these processes, and discuss the role of replication in regulating transcription.
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