Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long-circulating (sterically stabilized) liposomes for targeted drug delivery

T M Allen1

  • 1Department of Pharmacology, University of Alberta, Edmonton, Canada.

Trends in Pharmacological Sciences
|July 1, 1994
PubMed
Summary

Targeted liposome drug delivery reduces chemotherapy side effects. Sterically stabilized liposomes carrying doxorubicin eradicated tumors in mice, showing promise for cancer treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aetiology of Dental Caries.

The American journal of dental science·2019
Same author

Lipid nanoparticle delivery systems for siRNA-based therapeutics.

Drug delivery and translational research·2015
Same author

Within-session responding as a function of post-session feedings.

Behavioural processes·2014
Same author

Association of the family environment with behavioural and cognitive outcomes in children with chromosome 22q11.2 deletion syndrome.

Journal of intellectual disability research : JIDR·2013
Same author

Randomized multicenter clinical trial of myofascial physical therapy in women with interstitial cystitis/painful bladder syndrome and pelvic floor tenderness.

The Journal of urology·2012
Same author

Low-power resonant laser ablation of copper.

Applied optics·2010

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Chemotherapy's efficacy is hampered by severe side effects due to toxicity in normal tissues.
  • Targeted drug delivery systems are crucial for improving therapeutic outcomes and minimizing systemic toxicity.
  • Sterically stabilized liposomes offer prolonged circulation times for enhanced in vivo drug delivery.

Purpose of the Study:

  • To review the application of sterically stabilized liposomes for targeted anticancer drug delivery.
  • To evaluate the efficacy of antibody-targeted liposomes in a preclinical cancer model.

Main Methods:

  • Utilized sterically stabilized liposomes encapsulating doxorubicin.
  • Conjugated specific antibodies to the liposome surface for targeting squamous cell lung carcinoma.

Related Experiment Videos

  • Assessed tumor burden reduction and eradication rates in a murine model.

    • Main Results:

    • Sterically stabilized liposomes demonstrated effective in vivo drug delivery due to extended circulation.
    • Targeted liposomes significantly reduced tumor burden in mice.
    • A notable percentage of mice achieved complete tumor eradication.

    Conclusions:

    • Antibody-targeted sterically stabilized liposomes show significant potential for treating squamous cell lung carcinoma.
    • This targeted drug delivery approach effectively reduces tumor burden and can lead to tumor eradication.
    • Liposome-based drug delivery offers a promising strategy to mitigate chemotherapy-induced side effects.