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[Osteoporosis-profile--a bad examination?]
O H Sørensen1, S P Nielsen, J Thode
1Kommunehospitalet, København.
Ugeskrift for Laeger
|September 19, 1994
Summary
The osteoporosis-profile test for predicting bone loss in women is unreliable. Diet variations caused significant fluctuations, rendering the test useless for individual assessment.
Area of Science:
- Endocrinology
- Bone Metabolism
- Clinical Diagnostics
Context:
- The osteoporosis-profile, a diagnostic tool estimating future bone loss, is gaining traction among Danish physicians.
- It utilizes serum osteocalcin, alkaline phosphatases, and urinary calcium/hydroxyproline excretions to assess bone formation and resorption.
- The test is particularly aimed at peri- and postmenopausal women.
Purpose:
- To evaluate the clinical utility and reliability of the osteoporosis-profile test.
- To determine if dietary changes impact the accuracy of bone loss estimations.
- To assess the test's validity for individual patient diagnosis.
Summary:
- The osteoporosis-profile was administered to six women aged 46-56 over three weekends with varying diets.
- Each weekend concluded with a collagen-free meal and overnight fast to standardize the testing conditions.
- Observed individual variations in estimated bone loss reached 200-300% due to dietary influences.
Impact:
- The study demonstrates that the osteoporosis-profile is not a reliable indicator of bone loss in individuals.
- Dietary modifications significantly affect the test's results, compromising its diagnostic value.
- The findings question the widespread clinical application of this specific osteoporosis assessment tool.