[The characteristics of the hormonal status in women with bladder neoplasms]

In a controlled trial a gynecological history has been studied for 154 females with bladder tumors against 213 matched women without the tumor. The risk to develop the tumor was found to rise with the history of a short reproductive period, abortions, primary infertility, cancer of the corpus uteri and of the breast, ovarian cysts. Tryptophan metabolism assessed in 242 and 541 women and men with bladder cancer and free of it, respectively, was indicative of more frequent urinary registration of carcinogenic tryptophan metabolite 3-oxyantranilic acid: for females 40.5 per 100 in case of cancer, 10 per 100 in healthy ones; for males with cancer 33.9, without cancer 7.4 per 100 examinees. Radioimmunoassays of hormone concentrations in the serum with correlation to tryptophan metabolism for 55 cancer and 49 healthy females showed lowered levels of progesterone, folitropin and lutropine to occur more often in cancer women with urinary 3-oxyantranilic acid. The above endogenic factors analyzed retrospectively suggest involvement of hormonal status alterations in bladder cancer onset.