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[Fibronectin and its significance in pyelonephritis]
Urologiia I Nefrologiia
|May 1, 1993
Summary
High fibronectin levels are linked to pyelonephritis and cystitis, with fibronectin potentially aiding bacterial elimination and reducing kidney damage in pyelonephritis treatment.
Area of Science:
- Urology
- Immunology
- Biochemistry
Background:
- Urinary tract infections, including pyelonephritis and cystitis, are common.
- Fibronectin is a key protein in immune response and tissue repair.
Purpose of the Study:
- To investigate fibronectin levels in patients with pyelonephritis and chronic cystitis.
- To explore the therapeutic potential of fibronectin in experimental pyelonephritis.
Main Methods:
- Enzyme immunoassay was used to measure fibronectin levels in patient blood samples.
- Neutrophil phagocytic capacity was assessed after fibronectin preincubation.
- Exogenous fibronectin was administered in a murine model of pyelonephritis.
Main Results:
- Significantly elevated fibronectin levels were observed in patients with chronic cystitis and non-obstructive pyelonephritis.
- Hypofibronectinemia occurred in 23.3% of chronic pyelonephritis patients.
- Exogenous fibronectin enhanced bacterial clearance, reduced inflammation, prevented kidney damage, and improved immune cell function in experimental pyelonephritis.
Conclusions:
- Fibronectin levels are altered in patients with urinary tract infections.
- Fibronectin demonstrates therapeutic potential for treating pyelonephritis by enhancing immune response and protecting renal tissue.