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The 2A proteinase of human rhinovirus is a zinc containing enzyme
W Sommergruber1, G Casari, F Fessl
1BENDER+CO Ges. mbH, Department of Cell Biology, Vienna, Austria.
Virology
|November 1, 1994
Abstract:
The 2A proteinase of human rhinovirus (HRV) 2 is a cysteine proteinase which is not inhibited by metal chelating agents. However, total hydrolysis of highly purified HRV2 2A followed by atom emission spectroscopy demonstrated that HRV2 2A contains 1 mol of zinc per mole of enzyme. Furthermore, Zn depletion of the enzyme led to a loss of proteolytic activity which could subsequently be restored by Zn supplementation.