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Updated: Aug 13, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

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[The importance of doppler echocardiography in type I diabetics]

J Chlumský1, L Dvoráková

  • 1Interní oddĕlení Nemocnice Milosrdných sester sv. Karla Boromejského Praha.

Vnitrni Lekarstvi
|August 1, 1994
PubMed

Insights

Type 1 diabetes impairs mitral flow dynamics, indicated by elevated A/E ratio and isovolumic relaxation time (IVRT). These diastolic dysfunction markers correlate with diabetes control and microalbuminuria, suggesting Doppler echocardiography

Area of Science:

  • Cardiology
  • Diabetology
  • Medical Imaging

Background:

  • Diastolic dysfunction, characterized by impaired mitral flow, is common in conditions like hypertension and diabetes.
  • Type 1 diabetes (T1D) is associated with cardiovascular complications, including diastolic dysfunction.

Purpose of the Study:

  • To investigate diastolic function in type 1 diabetic patients using Doppler echocardiography.
  • To explore the relationship between diastolic parameters, microalbuminuria, diabetes duration, and glycemic control.

Main Methods:

  • Doppler echocardiography was used to assess the early and late peak flow velocity ratio (A/E) and left ventricular isovolumic relaxation time (IVRT).
  • 40 type 1 diabetic patients were compared with 40 age- and sex-matched non-diabetic controls.

Main Results:

  • Diabetic patients exhibited significantly higher A/E ratios and IVRT values compared to controls (p < 0.001).
  • Elevated A/E and IVRT were observed in diabetics with microalbuminuria and those with poorer diabetes compensation (p < 0.05).
  • No significant correlation was found with diabetes duration, and parameters remained stable over six months.

Conclusions:

  • Type 1 diabetes is associated with impaired diastolic function, detectable by Doppler echocardiography.
  • Microalbuminuria and suboptimal glycemic control are linked to more pronounced diastolic abnormalities in T1D.
  • Doppler echocardiography shows potential as a non-invasive tool for assessing diabetic complications.

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