Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The cytokine network in multiple myeloma]

J Bacovský1, V Scudla

  • 1III. interní klinika LF UP Olomouc.

Vnitrni Lekarstvi
|August 1, 1994
PubMed
Summary

This review examines cytokine network roles in multiple myeloma (MM) development and treatment. It highlights interleukin-6 (IL-6) and other cytokines

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Assessment of Heavy/ Light Chain Pairs of Immunoglobulin (Hevylite assay) -  Benefit for Stratification of Multiple Myeloma?].

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2015
Same author

Immunoparesis in MGUS - Relationship of uninvolved immunoglobulin pair suppression and polyclonal immunoglobuline levels to MGUS risk categories.

Neoplasma·2015
Same author

Histomorphometric diagnostics of renal osteopathy in chronic dialysis patients at high risk of cardiovascular disease.

International urology and nephrology·2015
Same author

[Attainment of complete hematological remission is crucial for extended survival of AL amyloidosis patients with cardiac involvement].

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2013
Same author

[The importance of cardiac bio-marker assay for the stratification and monitoring of AL amyloidosis patients -  single center experience].

Vnitrni lekarstvi·2013
Same author

[Treatment of AL amyloidosis in 2012; the benefit of new drugs (bortezomib, thalidomide, and lenalidomide). Summary of published clinical trials].

Vnitrni lekarstvi·2013

Area of Science:

  • Immunology and oncology, focusing on cytokine signaling in hematological malignancies.

Context:

  • Multiple myeloma (MM) is a hematological cancer characterized by uncontrolled plasma cell proliferation.
  • The cytokine network plays a critical role in MM pathogenesis, influencing disease progression and treatment response.

Purpose:

  • To review current understanding of cytokine network components in MM development, prognosis, and therapy.
  • To elucidate the specific roles of various cytokines, including IL-6, in MM, both in vitro and in vivo.

Summary:

  • The review emphasizes the central role of interleukin-6 (IL-6) as a key growth factor for myeloma cells.
  • It also discusses the involvement of other cytokines (e.g., IL-1, TNF, interferons) and their impact on MM progression and osteolytic lesions.
  • Potential therapeutic strategies targeting IL-6 and interferons are explored.

Impact:

  • Provides a comprehensive overview of cytokine involvement in MM, aiding researchers and clinicians.
  • Highlights potential therapeutic targets within the cytokine network for improved MM treatment strategies.

Related Experiment Videos