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Related Experiment Videos

[Estrogens and cardiovascular diseases: should current guidelines be changed?]

F Beller1, W Theiss

  • 1Department of Obstetrics and Gynecology, Medical College, University of Iowa City.

Zentralblatt Fur Gynakologie
|January 1, 1994
PubMed
Summary

This study surveys oral contraceptives and hormonal therapy, finding no link between phlebitis/varicosis and thromboembolic disorders. Current guidelines on stopping oral contraceptives before surgery require more evidence.

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Area of Science:

  • Coagulation science
  • Endocrinology
  • Gynecology

Context:

  • Oral contraceptives (OCs) and postmenopausal hormone replacement therapy (HRT) are widely used.
  • Their impact on the coagulation system is a significant clinical concern, particularly regarding thromboembolic risk.
  • Pre-operative management of OCs requires careful consideration due to potential bleeding or clotting risks.

Purpose:

  • To survey the effects of oral contraceptives and postmenopausal hormonal replacement therapy on the coagulation system.
  • To evaluate the necessity and sufficiency of evidence for withdrawing oral contraceptives before gynecological surgery.
  • To review contraindications and potential future changes in guidelines regarding oral contraceptive use and thromboembolic disorders.

Summary:

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  • The survey discusses the pros and cons of oral contraceptives and HRT concerning coagulation.
  • While a history of thromboembolic disorders remains a contraindication for OCs, this may evolve.
  • No etiological link was found between phlebitis or varicosis and thromboembolic disorders during OC use.

    • Impact:

    • Highlights the need for more robust evidence regarding pre-operative OC withdrawal protocols.
    • Suggests that current contraindications for OCs in patients with thromboembolic history may be revised.
    • Provides clarity on the lack of association between superficial venous issues and serious thromboembolic events with OC use.