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[The pathogenetic role of circulating immune complexes in multiple sclerosis]
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|January 1, 1994
Summary
Circulating immune complexes (CIC) in multiple sclerosis contain antibodies to various tissues. Hormone therapy positively impacts CIC levels in these patients.
Area of Science:
- Neuroimmunology
- Immunopathology
- Endocrinology
Background:
- Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system.
- Circulating immune complexes (CIC) are implicated in autoimmune conditions.
- The role of CIC in MS pathogenesis requires further elucidation.
Purpose of the Study:
- To qualitatively and quantitatively assess CIC in multiple sclerosis patients.
- To investigate the impact of hormone therapy on CIC levels in MS.
Main Methods:
- Qualitative and quantitative analysis of CIC.
- Assessment of CIC levels before and after hormone therapy.
Main Results:
- CIC in multiple sclerosis patients were found to contain antibodies targeting brain tissue, thymus, hepatic lipoprotein, adrenal cortex, leukocytes, and gastric mucosa.
- A positive correlation was observed between hormone treatment and changes in CIC levels.
Conclusions:
- CIC in MS are complex and target multiple self-antigens.
- Hormone therapy demonstrates a beneficial effect on modulating CIC levels in multiple sclerosis.