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Hypocholesterolemia and affective disorders

C J Glueck1, M Tieger, R Kunkel

  • 1Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229.

The American Journal of the Medical Sciences
|October 1, 1994
PubMed
Summary

Patients hospitalized with affective disorders show significantly lower cholesterol levels compared to the general population. This study did not find evidence that low cholesterol causes or worsens mood disorders.

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Area of Science:

  • Psychiatry
  • Cardiovascular Health
  • Metabolic Disorders

Background:

  • Hypocholesterolemia, or low cholesterol, is a condition that warrants further investigation, particularly in relation to mental health.
  • Previous research has suggested potential links between cholesterol levels and affective disorders, but comprehensive comparisons are needed.

Purpose of the Study:

  • To investigate the prevalence of hypocholesterolemia in patients hospitalized for affective disorders.
  • To compare cholesterol levels in these patients against general population samples.

Main Methods:

  • A comparative study involving 203 patients with affective disorders (depression, bipolar disorder, schizoaffective disorder).
  • Comparison groups included 1,595 supermarket screenees and 11,864 participants from the National Health and Nutrition Examination Survey II.

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  • Analysis included plasma total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels, adjusted for age and sex.

    • Main Results:

    • Low plasma cholesterol (< 160 mg/dL) was significantly more common in patients with affective disorders (20%) compared to supermarket screenees (4%) and NHANES II (10%).
    • Patients with affective disorders exhibited lower total cholesterol, LDL, and HDL cholesterol, and higher triglycerides when compared to age- and sex-matched controls.
    • No significant association was found between affective disorder severity, psychoactive medications, and cholesterol levels, though age showed a positive correlation.

    Conclusions:

    • Hospitalized patients with affective disorders demonstrate a marked downward shift in plasma cholesterol concentrations towards hypocholesterolemic levels.
    • The study found no evidence to support the hypothesis that low plasma cholesterol causes or exacerbates affective disorders.