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Amniotic fluid volume reflects recent glycemic status in gestational diabetes mellitus
I Bar-Hava1, S A Scarpelli, Y Barnhard
1Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10461.
Objective:
Our purpose was to determine the association between amniotic fluid volume and recent glucose status in gestational diabetes.
Study Design:
Serial amniotic fluid index values, mean blood glucose levels, and percent hyperglycemia (> or = 120 mg/dl) 1 day and 1 week before the ultrasonographic examinations were prospectively collected in 399 gestational diabetics. Patients demonstrating at least one amniotic fluid index measurement within the normal range (i.e., 5 cm < amniotic fluid index < or = 20 cm) and at least one elevated measurement (i.e., amniotic fluid index > 20 cm) formed the study group. With each patient serving as her own control, glucose index values preceding normal and elevated amniotic fluid index values were compared.
Results:
Significantly higher mean blood glucose values 1 day (114.7 mg/dl vs 102.8 mg/dl, p < 0.01) and 1 week before (111.0 mg/dl vs. 102.0 mg/dl, p < 0.05) were calculated for examinations resulting in elevated amniotic fluid index values compared with normal amniotic fluid index values, respectively. Similarly, significantly higher percents of hyperglycemia 1 day (32% vs 16.5%, p < 0.05) but not 1 week (30.8% vs 21.7%, p > 0.05) before the elevated amniotic fluid index were documented.
Conclusion:
Amniotic fluid volume reflects recent glycemic status in gestational diabetes mellitus.