Related Experiment Videos
Antidepressant-associated mania: a controlled comparison with spontaneous mania
A L Stoll1, P V Mayer, M Kolbrener
1Bipolar and Psychotic Disorders Program, Mailman Research Center, McLean Hospital, Belmont, Mass.
The American Journal of Psychiatry
|November 1, 1994
Summary
Antidepressant-associated mania presents as a milder, shorter condition compared to spontaneous mania. This suggests it may be a distinct clinical syndrome, with certain antidepressants linked to less severe episodes.
Area of Science:
- Psychiatry and Clinical Psychology
- Neuroscience and Pharmacology
Background:
- Antidepressants are known to potentially induce manic episodes or rapid cycling in susceptible individuals.
- Understanding the characteristics of antidepressant-associated mania is crucial for accurate diagnosis and management.
Purpose of the Study:
- To investigate and compare the clinical features of antidepressant-associated manic states with spontaneous manic episodes.
- To determine if antidepressant-induced mania represents a distinct clinical entity.
Main Methods:
- A blind, retrospective chart review was conducted.
- Forty-nine inpatients with antidepressant-associated mania were compared to 49 matched inpatients with spontaneous mania.
Main Results:
- Antidepressant-associated manic states were characterized by milder and shorter episodes across most clinical measures.
- Patients with antidepressant-associated mania experienced significantly less severe delusions, hallucinations, psychomotor agitation, and bizarre behavior.
- Monoamine oxidase inhibitors (MAOIs) and bupropion were associated with milder mania compared to tricyclics or fluoxetine.
Conclusions:
- Antidepressant-associated mania appears to be a milder and more time-limited syndrome than spontaneous mania.
- This condition may represent a distinct clinical entity.
- MAOIs and bupropion may be linked to milder manic states compared to tricyclic drugs or fluoxetine.