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Effects of low-dose TRH on cognitive deficits in the ECT postictal state

A Khan1, M H Mirolo, K Claypoole

  • 1Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195.

The American Journal of Psychiatry
|November 1, 1994
PubMed

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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...