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Updated: Jul 31, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
Published on: May 16, 2016
[Ways of increasing effectiveness of emergency detoxication in acute exo- and endotoxicoses]
Abstract:
The experience in complex detoxication in acute poisonings and endotoxemias (sepsis, burn-induced toxemia, alcohol and narcotic abstinence, acute hepatorenal failure) has been analysed. The efficacy of various detoxication techniques have been assessed. The techniques compared were sorption dialysis and pharmacological ones, as well as physiohemotherapy as part of magnetic and UV hemotherapy, enhancing the detoxicating process and facilitating adequate correction of homeostasis parameters at all stages of toxemia management. It has been found that hemosorption has the greatest effect on the kinetics of toxic compounds, while physiohemotherapy has the greatest effect on homeostasis parameters. Rational approach to complex detoxication leads to the improvement in treatment results.
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