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Related Experiment Videos

Treating cancer: is kill cure?

H Schipper1

  • 1WHO Collaborating Centre for Quality of Life in Cancer Care Manitoba Cancer Foundation, University of Manitoba, Canada.

Annals of the Academy of Medicine, Singapore
|May 1, 1994
PubMed
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See all related articles

The traditional cancer "kill/cure" model may be limiting progress. A new paradigm views cancer cells as aberrantly regulated, suggesting control, not just cell killing, is key to effective cancer therapies.

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • The dominant cancer research paradigm focuses on eradicating irreversibly damaged cells.
  • This
  • kill/cure
  • approach has been the foundation for over fifty years of cancer research and treatment.
  • However, evidence suggests this paradigm is reaching its limits and may obscure alternative control mechanisms.

Purpose of the Study:

  • To challenge the established
  • kill/cure
  • paradigm in cancer research.
  • To propose a new model viewing cancer cells as aberrantly regulated rather than irreversibly damaged.
  • To explore how this new conceptualization can explain existing observations and guide future therapies.

Related Experiment Videos

Main Methods:

  • Review and synthesis of existing data from cancer research and clinical observations.
  • Conceptual re-evaluation of cancer as a dynamic system of cellular communication and regulation.
  • Development of a novel model for understanding cancer cell behavior and treatment response.

Main Results:

  • Cancer cell dysfunction, while profound, often derives from normal cellular mechanisms for growth, repair, and renewal.
  • Cytotoxic approaches may inadvertently worsen communication defects that drive cancer progression.
  • A new model posits cancer cells are aberrantly regulated, and
  • cures
  • may result from reasserting control, not solely from cell death.

Conclusions:

  • The
  • kill/cure
  • paradigm may be insufficient for comprehensive cancer control.
  • Viewing cancer as aberrantly regulated opens new avenues for therapeutic strategies and evaluation.
  • This conceptual shift explains phenomena like drug resistance and graft-versus-host disease's link to remission.