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Related Experiment Videos

Sialic acid as a tumor marker

S Narayanan1

  • 1Department of Pathology, New York Medical College-Metropolitan Hospital Center, NY 10029.

Annals of Clinical and Laboratory Science
|July 1, 1994
PubMed
Summary

Sialic acid, a molecule involved in cell functions, shows potential as a tumor marker due to cancer-related cell membrane changes. While sensitive, its specificity is limited, but it aids in monitoring cancer treatment effectiveness.

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Area of Science:

  • Biochemistry
  • Oncology
  • Cell Biology

Background:

  • Sialic acids are neuraminic acid derivatives with unique structures, including a negative charge, enabling roles in cellular functions like transport and cell adhesion.
  • Aberrant glycosylation in cancer involves altered sialic acid expression on cell membranes, impacting tumor cell behavior.
  • Sialic acid plays a role in tumor metastasis, enhancing adherence to endothelium and evading host defenses.

Purpose of the Study:

  • To examine the role of sialic acid as a tumor marker in cancer.
  • To investigate the significance of aberrant glycosylation and sialic acid in tumor cell metastasis.
  • To evaluate the utility of sialic acid measurements in monitoring cancer patients.

Main Methods:

  • Review of existing literature on sialic acid's role in cancer.
  • Analysis of sialic acid's involvement in aberrant glycosylation and metastasis.
  • Discussion of various measurement techniques for sialic acid in serum/plasma.

Main Results:

  • Sialic acid exhibits high sensitivity as a tumor marker across various cancers.
  • Specificity is limited due to increased levels in inflammatory conditions.
  • Sialic acid measurements are valuable for monitoring cancer patient treatment.

Conclusions:

  • Sialic acid's altered expression is linked to cancer development and metastasis.
  • Despite limited specificity, sialic acid serves as a useful biomarker for monitoring cancer treatment.
  • Advanced methods like HPLC offer sensitive and reliable sialic acid detection.

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