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[An experimental study on liver hyperthermia using intraperitoneal hyperthermic perfusion (IPHP)]

T Kitagawa1, Y Ku, Y Saitoh

  • 1First Dept. of Surgery, Kobe University School of Medicine.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|September 1, 1994
PubMed
Summary
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Intraperitoneal hyperthermic perfusion (IPHP) effectively heats the liver in rabbits. This method shows promise as a simple and safe technique for liver hyperthermia treatment.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Physics

Context:

  • Regional hyperthermia is a promising cancer treatment modality.
  • Accurate temperature monitoring is crucial for hyperthermia efficacy and safety.
  • Developing effective and safe methods for liver hyperthermia is an ongoing challenge.

Purpose:

  • To evaluate the efficacy and safety of intraperitoneal hyperthermic perfusion (IPHP) for regional liver hyperthermia.
  • To assess the temperature distribution within the abdominal cavity and liver during IPHP in a rabbit model.
  • To compare liver temperatures with temperatures in surrounding organs like the rectum and esophagus.

Summary:

  • IPHP involves infusing warm saline (46-48°C) into the abdominal cavity of white rabbits.

Related Experiment Videos

  • Temperatures in the abdominal cavity, portal vein, and liver parenchyma reached therapeutic levels (41.5-42.6°C) within 30-60 minutes.
  • Temperatures in the rectum and esophagus remained below critical levels (<39.2°C and <40.4°C, respectively), indicating a favorable safety profile.

    • Impact:

    • IPHP demonstrates potential as a simple and effective method for achieving therapeutic liver hyperthermia.
    • The study provides evidence supporting the feasibility of IPHP for clinical application in liver cancer treatment.
    • This technique may offer a localized and controlled approach to hyperthermia, minimizing systemic side effects.