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Related Experiment Videos

Dose-response studies with protirelin

J C Garbutt1, J P Mayo, K Y Little

  • 1Department of Psychiatry, University of North Carolina at Chapel Hill.

Archives of General Psychiatry
|November 1, 1994
PubMed
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Major depression in men is linked to reduced thyroid-stimulating hormone (TSH) and prolactin (PRL) responses to thyrotropin-releasing hormone (TRH), suggesting downregulated TRH receptors. Findings in women were less conclusive.

Area of Science:

  • Neuroendocrinology
  • Psychiatry
  • Endocrinology

Background:

  • A subset of patients with major depression exhibits a blunted thyrotropin (TSH) response to thyrotropin-releasing hormone (protirelin [TRH]).
  • This observation supports the hypothesis of downregulated pituitary TRH receptors in major depression.
  • Consequently, attenuated TSH and prolactin (PRL) responses to TRH are predicted.

Purpose of the Study:

  • To investigate the dose-response relationship of protirelin-induced TSH and PRL secretion in patients with major depression compared to controls.
  • To test the hypothesis of downregulated TRH receptors in major depression by examining TSH and PRL responses.

Main Methods:

  • Four ascending doses of protirelin (25-800 mcg) were administered to patients with major depression and age/gender-matched controls.

Related Experiment Videos

  • TSH and PRL levels were measured post-infusion across different protirelin doses.
  • Seven men and seven women with depression were compared to controls.

    • Main Results:

    • No significant baseline differences in thyroid hormones or cortisol between groups.
    • Depressed men showed significantly reduced TSH and PRL responses to all protirelin doses compared to control men.
    • Depressed women displayed reduced TSH responses but not PRL responses compared to control women.

    Conclusions:

    • Reduced TSH and PRL responses to protirelin in depressed men support the TRH receptor downregulation hypothesis in depression.
    • The less clear findings in women may be attributed to greater variability in PRL responses.
    • Further research is needed to clarify the neuroendocrine differences in depression between sexes.