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Loin pain-hematuria syndrome with a distinctive vascular lesion and alternative pathway complement activation
1Department of Pathology, School of Medicine, State University of New York-Stony Brook 11794-8691.
Abstract:
We describe a 48-year-old woman with loin pain-hematuria syndrome. Her renal abnormalities included conspicuous microaneurysmal and glomeruloid (plexiform) angiomatous changes. The deposition of both properdin and the C5b-9 complex, as well as the usual C3, in arterioles argues for complement activation. To our knowledge, neither of these features has been previously described. We speculate about the cause of loin pain-hematuria syndrome and note the uncommonness of this entity in the United States as opposed to Great Britain.
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