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Analytical-physical profile of the novel macrolide antibiotic flurithromycin ethylsuccinate
N Colombo1, A Depaoli, M Gobetti
1R & D Chemistry and Pharmacy Department, Pierrel S.p.A., Milan, Italy.
Arzneimittel-Forschung
|July 1, 1994
Abstract:
Data are reported on the structural characterization of flurithromycin ethylsuccinate (FE, CAS 82730-23-2), a novel macrolide antibiotic. UV, IR, NMR and MS spectra confirmed the structure; in particular the presence of ketonic-hemiketalic equilibrium, already described for flurithromycin A, is supported by NMR and HPLC studies. Moreover physico-chemical properties and stability were studied; the product exhibits a good stability at solid state, whereas degradation products are present both in acidic and basic solution. Microbiological activity and principal pharmaceutical features were carried out.