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Synthesis and beta-lactamase inhibitory activity of new 6 beta-sulfonamidopenicillanic acids
L S Changov1, B K Vassileva-Lukanova, A Angelova-Galabova
1Chemical Pharmaceutical Research Institute, Bulgarian Academy of Sciences, Sofia.
Arzneimittel-Forschung
|July 1, 1994
Abstract:
New 6 beta-aryl(alkyl)sulfonamidopenicillanic acids and their sulfoxides were synthesized by sulfonylation of 6 beta-aminopenicilanic acid or its beta-sulfoxide with an appropriate sulfonyl chloride. The corresponding 6 beta-sulfonamidopenicillanic acids sulfones were prepared by oxidation of the sulfoxides with potassium permanganate in aqueous medium. The obtained compounds reduced the minimum inhibitory concentrations of ampicillin against 8 reference and 7 clinically isolated strains.