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Synthesis of substituted [1]benzothieno[2,3-b]pyrazines and their ability to antagonize KCl induced contractions
F Guerrera1, L Salerno, M C Sarvà
1Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|July 1, 1994
Abstract:
A series of substituted [1]benzothieno [2,3-b]pyrazines, structurally related to caroverine, was synthesized. Some of these compounds showed an appreciable inhibition towards KCl induced contractions on isolated rat aortic rings, and a lower potency towards negative inotropic activity tested on isolated guinea pig atrium.