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Synthesis and in vitro anti-HIV activity of novel delta 2-1,2,4-oxadiazoline derivatives
A Chimirri1, S Grasso, A M Monforte
1Dipartimento Farmaco-Chimico, Università di Messina, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|July 1, 1994
Abstract:
The synthesis of 4-adamantyl-5-aryl-3-phenyl-delta 2-1,2,4-oxadiazolines, involving an 1,3-dipolar cycloaddition reaction between 1-[(arylidene)amino]adamantanes and benzonitriloxide, is described. The evaluation of in vitro antiviral activity against human immunodeficiency virus (HIV) of the compounds obtained is also reported.