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[An orthogonal method for comparing extracting techniques of licorice root extract]

W A Huang¹, Y Meng, P L Huang

¹Guangxi, Yulin pharmaceutical Factory.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|May 1, 1994

Summary

Optimizing licorice root extraction with 60% alcohol and ammonia yielded over 10% glycyrrhizic acid recovery. This method significantly outperformed water extraction for this key compound.

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Area of Science:

Pharmacognosy
Natural Product Chemistry
Analytical Chemistry

Background:

Licorice root (Glycyrrhiza glabra) is a valuable medicinal herb.
Glycyrrhizic acid is a primary bioactive compound in licorice root.
Efficient extraction methods are crucial for maximizing glycyrrhizic acid yield.

Purpose of the Study:

To optimize the extraction of glycyrrhizic acid from licorice root.
To compare different extraction parameters including solvent, frequency, and particle size.
To identify the most effective method for glycyrrhizic acid recovery.

Main Methods:

Utilized a L9(3(4)) orthogonal experimental design.
Investigated variables: licorice root size, extraction solvent (60% alcohol with 0.3% ammonia), and extraction frequency.

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Assessed glycyrrhizic acid recovery as the primary evaluation criterion.

Main Results:

The optimal extraction involved comminuted licorice root.
Extraction with 60% alcohol containing 0.3% ammonia, repeated three times, yielded the highest glycyrrhizic acid recovery.
Achieved over 10% glycyrrhizic acid recovery, approximately 7% higher than water extraction.

Conclusions:

The optimized orthogonal method provides a superior approach for licorice root extraction.
The combination of specific solvent composition, particle size, and multiple extractions significantly enhances glycyrrhizic acid yield.
This method offers a more efficient alternative to traditional water extraction for obtaining glycyrrhizic acid.