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CD8+ T-cell memory to viruses

P C Doherty1, S Hou, R A Tripp

  • 1St Jude Children's Research Hospital, Memphis, Tennessee 38101-0318.

Current Opinion in Immunology
|August 1, 1994
PubMed

Recent experiments show that laboratory mice infected once with an influenza A virus or with the murine parainfluenza type 1 virus, called the Sendai virus, have enhanced numbers of cytotoxic T-lymphocyte precursors ( > 20x background) for life. Neither virus persists at the genome level, and the mice are maintained under conditions where there is no possibility of re-infection. These observations are highly relevant to any understanding of CD8+ cell memory and suggest that the clonal burst size associated with the primary challenge is a key determining factor.

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