Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

2',3'-Didehydro-2',3'-dideoxy-5-hydroxymethyluridine

U Pugazhenthi1, L T Delbaere, S V Kumar

  • 1Department of Chemistry, University of Saskatchewan, Saskatoon, Canada.

Acta Crystallographica. Section C, Crystal Structure Communications
|August 15, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults: analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS).

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Soil Moisture Data Assimilation to Estimate Irrigation Water Use.

Journal of advances in modeling earth systems·2020
Same author

Diversity in fall characteristics hampers effective prevention: the precipitants, the environment, the fall and the injury.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2017
Same author

Single versus double blade technique for skin incision and deep dissection in surgery for closed fracture: a prospective randomised control study.

Journal of orthopaedic surgery (Hong Kong)·2016
Same author

Physical health comorbidities in women with personality disorder: Data from the Geelong Osteoporosis Study.

European psychiatry : the journal of the Association of European Psychiatrists·2016
Same author

Erratum to: Complete chloroplast genome sequence of MD-2 pineapple and its comparative analysis among nine other plants from the subclass Commelinidae.

BMC plant biology·2015

This study details the specific three-dimensional structure of a molecule, C10H12N2O5, focusing on its furanose ring conformation and key torsion angles. Understanding this molecular geometry is crucial for nucleoside analog research.

Area of Science:

  • Structural Chemistry
  • Molecular Biology
  • Crystallography

Background:

  • Nucleoside analogs are vital in antiviral and anticancer therapies.
  • Precise knowledge of their three-dimensional structure is essential for understanding their biological activity.
  • The furanose ring conformation significantly impacts nucleoside analog function.

Purpose of the Study:

  • To elucidate the detailed solid-state conformation of the molecule C10H12N2O5.
  • To characterize the furanose ring conformation and key torsion angles.
  • To provide structural data for nucleoside analog design and development.

Main Methods:

  • Single-crystal X-ray diffraction analysis was employed.
  • The molecular structure was determined and refined.

Related Experiment Videos

  • Conformational analysis of the furanose ring and substituent groups was performed.

    • Main Results:

    • The furanose ring of C10H12N2O5 adopts an O(4')-endo envelope conformation (0E).
    • The glycosidic torsion angle (chi) was determined to be 245.2(3) degrees.
    • The CH2OH group at C(5') exhibits a trans (t) conformation with a gamma angle of 179.2(2) degrees.

    Conclusions:

    • The study provides precise structural parameters for C10H12N2O5.
    • These findings contribute to the understanding of nucleoside analog structural diversity.
    • The determined conformation can inform the design of novel therapeutic agents.