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Is cow's milk protein intolerance a cause of gastro-oesophageal reflux in infancy?

B I McLain1, D J Cameron, G L Barnes

  • 1Department of Gastroenterology, Royal Children's Hospital, Parkville, Victoria, Australia.

Journal of Paediatrics and Child Health
|August 1, 1994
PubMed

Insights

Cow's milk protein intolerance (CMPI) rarely causes gastro-oesophageal reflux (GOR) in infants. A hypoallergenic diet did not significantly improve reflux symptoms or pH monitoring in infants with abnormal GOR.

Area of Science:

  • Pediatric Gastroenterology
  • Allergy and Immunology

Background:

  • Gastro-oesophageal reflux (GOR) is common in infants.
  • Cow's milk protein intolerance (CMPI) is a potential, though debated, contributor to GOR.
  • Conventional therapies often fail in persistent GOR cases.

Purpose of the Study:

  • To investigate the role of CMPI in infants with persistent, therapy-resistant GOR.
  • To determine if a hypoallergenic diet improves GOR indicators in this population.

Main Methods:

  • 10 infants with abnormal GOR (prolonged esophageal pH monitoring) unresponsive to standard treatment were enrolled.
  • Participants followed a hypoallergenic diet for one month.
  • Oesophageal pH monitoring and symptom assessment were used to evaluate treatment efficacy.

Main Results:

  • No significant improvement in pH monitoring indices was observed in any child.
  • Only two infants reported subjective symptomatic improvement.
  • CMPI did not appear to be a significant factor in passive GOR for this cohort.

Conclusions:

  • CMPI is unlikely to be a primary cause of passive GOR in infants unresponsive to conventional treatment.
  • The study does not rule out CMPI as a cause of active vomiting in infants.
  • Further research may be needed to explore CMPI's role in specific GOR presentations.

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