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Related Experiment Videos

How appropriate are commercially available human milk fortifiers?

R Metcalf1, B Dilena, R Gibson

  • 1Department of Paediatrics and Child Health, Flinders Medical Centre, Bedford Park, Australia.

Journal of Paediatrics and Child Health
|August 1, 1994
PubMed
Summary

This study compared two breast milk fortifiers (FM-85 and Enfamil Human Milk Fortifier) for premature infants. Both fortifiers supported similar growth and biochemical parameters, though preterm formula showed faster weight gain.

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Area of Science:

  • Neonatal Nutrition
  • Pediatric Gastroenterology
  • Clinical Pediatrics

Background:

  • Premature infants require specialized nutrition to support growth and development.
  • Breast milk is the preferred nutrition source, but often needs fortification for preterm infants.
  • Evaluating the efficacy of available breast milk fortifiers is crucial for clinical practice.

Purpose of the Study:

  • To compare the effectiveness of two commercially available breast milk fortifiers (FM-85 and Enfamil Human Milk Fortifier) in preterm infants.
  • To assess growth parameters and biochemical markers in infants receiving fortified breast milk.
  • To compare outcomes with a standard preterm formula.

Main Methods:

  • A randomized investigation involving preterm infants (<1800g, <34 weeks gestation) receiving breast milk.

Related Experiment Videos

  • Infants were assigned to receive either FM-85 (n=14) or Enfamil Human Milk Fortifier (n=10) until reaching 2kg.
  • A control group (n=9) received preterm formula (Prenan). Growth and plasma parameters were monitored.

    • Main Results:

    • Both FM-85 and Enfamil Human Milk Fortifier groups demonstrated similar weight gain, head circumference growth, and arm muscle/fat area growth.
    • Plasma calcium, phosphate, copper, and zinc levels were comparable between the two fortifier groups.
    • The preterm formula group exhibited a higher rate of weight gain and arm fat area growth compared to the fortifier groups.

    Conclusions:

    • Both FM-85 and Enfamil Human Milk Fortifier are effective in supporting growth and maintaining biochemical parameters in preterm infants receiving breast milk.
    • While both fortifiers performed similarly, preterm formula led to faster weight gain.
    • Further research may be warranted to optimize nutritional strategies for extremely preterm infants.