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Related Experiment Videos

[Diffusion anisotropy in cerebral white matter lesion]

F Segawa1, J Kishibayashi, K Kamada

  • 1Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan.

No to Shinkei = Brain and Nerve
|August 1, 1994
PubMed
Summary

Diffusion MRI differentiates white matter lesions by revealing changes in apparent diffusion coefficients. This technique helps distinguish demyelinating processes from secondary degeneration in white matter diseases.

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Area of Science:

  • Neuroimaging
  • White Matter Diseases
  • Diffusion MRI

Context:

  • T2-weighted MRI shows diffuse high-signal lesions in cerebral white matter.
  • Various conditions like adrenoleukodystrophy, dentato-rubro-pallido-luysian atrophy, and others were studied.
  • Some cortical lesions showed low signal on T2-weighted images.

Purpose:

  • To evaluate the utility of diffusion-weighted MRI in characterizing white matter lesions.
  • To differentiate between demyelinating processes and secondary degeneration in white matter.

Summary:

  • Diffusion-weighted MRI revealed significantly higher apparent diffusion coefficients perpendicular to nerve fibers in frontal white matter and corpus callosum in most patients compared to controls.
  • Lesions showed increased diffusion anisotropy, indicating a loss of anisotropy suggestive of demyelination.

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  • In two cases with cortical involvement, diffusion parameters were normal, suggesting secondary degeneration.

    • Impact:

    • Diffusion-weighted MRI can differentiate between at least two types of white matter lesions, unlike T2-weighted MRI.
    • This technique aids in understanding the underlying pathology of white matter diseases.
    • Findings contribute to improved diagnosis and characterization of neurological disorders affecting white matter.