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[Pick's disease in senescence]

K Tsuchiya1, S Watabiki, K Owada

  • 1Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan.

No to Shinkei = Brain and Nerve
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

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Pick's disease, a rare neurodegenerative disorder, can manifest in senescence (old age). This study highlights two cases of late-onset Pick's disease presenting with behavioral changes and cognitive decline.

Area of Science:

  • Neurology
  • Geriatrics
  • Neurodegenerative Diseases

Background:

  • Pick's disease is a rare form of dementia characterized by frontotemporal lobar degeneration.
  • Onset typically occurs earlier in life, making late-onset cases particularly noteworthy.

Observation:

  • Two patients, aged 78 and 73, presented with late-onset Pick's disease.
  • Symptoms included abnormal behavior, easy angriness, cognitive impairment (slight dementia), and specific neurological findings.
  • Neuroimaging revealed bilateral frontal and temporal lobe atrophy in both patients.

Findings:

  • Patient 1 (78F) exhibited behavioral changes and dementia (WAIS IQ 62) with temporal lobe atrophy.
  • Patient 2 (73M) showed sexual disinhibition, cognitive decline (WAIS IQ 91), and frontal lobe atrophy.

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  • Both cases demonstrate Pick's disease presenting in senescence, a rare occurrence.

    • Implications:

    • Pick's disease should be considered in the differential diagnosis of abnormal behavior and dementia in the elderly.
    • Late-onset presentations challenge typical diagnostic criteria and highlight the need for broader consideration of rare dementias.
    • Further research into the pathogenesis and diagnosis of senescence-onset Pick's disease is warranted.