Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Salt intake, blood pressure, and cardiovascular structure

A H Beil1, R E Schmieder, F H Messerli

  • 1Department of Internal Medicine-Nephrology, University of Erlangen-Nürnberg, Germany.

Cardiovascular Drugs and Therapy
|June 1, 1994
PubMed
Summary

Low sodium intake may benefit blood pressure over a lifetime. However, salt restriction

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urocortin 2 - a protective effect in hypertension?

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2023
Same author

In vitro fertilization exacerbates stroke size and neurological disability in wildtype mice.

International journal of cardiology·2021
Same author

More SPRINT controversy.

Journal of internal medicine·2017
Same author

Optimal blood pressure targets in 2014 - Does the guideline recommendation match the evidence base?

Hipertension y riesgo vascular·2015
Same author

Cardioprotection with beta-blockers: myths, facts and Pascal's wager.

Journal of internal medicine·2009
Same author

Beta-blockers as fourth-line therapy for hypertension: stay the course.

International journal of clinical practice·2009

Area of Science:

  • Cardiovascular epidemiology
  • Renal physiology
  • Dietary salt impact

Background:

  • Epidemiologic data suggests low sodium intake may favorably influence blood pressure.
  • Sodium restriction can modestly lower blood pressure, but may raise it in some hypertensive patients.
  • Left ventricular hypertrophy is linked to cardiovascular morbidity and mortality, independent of other risk factors.

Purpose of the Study:

  • To explore the relationship between dietary salt intake and myocardial hypertrophy.
  • To investigate the mechanisms linking salt intake to myocardial hypertrophy.
  • To determine if salt restriction reduces cardiovascular structural damage independently of arterial pressure.

Main Methods:

  • Analysis of epidemiologic data on sodium intake and blood pressure.
  • Review of studies on sodium restriction effects in hypertensive patients.
  • Examination of the correlation between 24-hour urinary sodium excretion and left ventricular mass.
  • Investigation of potential mechanisms: renin-angiotensin-aldosterone system, sympathetic nervous system, and fluid volume homeostasis.

Main Results:

  • Dietary salt intake influences myocardial hypertrophy independently of other factors.
  • 24-hour urinary sodium excretion correlates with left ventricular mass, irrespective of arterial pressure.
  • Potential mechanisms linking salt intake to hypertrophy include the renin-angiotensin-aldosterone system, sympathetic nervous system, and fluid volume homeostasis.

Conclusions:

  • Dietary salt intake plays a role in myocardial hypertrophy through various physiological pathways.
  • The effect of salt restriction on cardiovascular structural damage independent of blood pressure remains undetermined.

Related Experiment Videos