Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitrates in congestive heart failure

J Dupuis1

  • 1Montreal Heart Institute, Québec, Canada.

Cardiovascular Drugs and Therapy
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

Nitrates improve congestive heart failure (CHF) by reducing heart pressure and improving function. A nightly nitrate-free interval is recommended to maintain effectiveness and avoid tolerance during daily activities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lymphomatoid papulosis associated with chronic lymphocytic leukaemia/small lymphocytic lymphoma: three cases.

The British journal of dermatology·2017
Same author

Clinical characteristics and prognostic factors of plasmablastic lymphoma patients: analysis of 135 patients from the LYSA group.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

[Noninvasive ventilation during pulmonary rehabilitation in COPD patients].

Revue des maladies respiratoires·2015
Same author

Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study.

Respiratory research·2015
Same author

A Study on UV Filter Chemicals from Annex VII of European Union Directive 76/768/EEC, in the In Vitro 3T3 NRU Phototoxicity Test.

Alternatives to laboratory animals : ATLA·2015
Same author

[A comparison of pulmonary rehabilitation delivered in the home or at a centre for patients with COPD].

Revue des maladies respiratoires·2014
Same journal

GLP-1 Agonists and Risk of Atrial Fibrillation in Non-Dialysis Chronic Kidney Disease.

Cardiovascular drugs and therapy·2026
Same journal

Methodological Considerations in Evaluating Plaque Stabilization in Patients with High Lipoprotein(a).

Cardiovascular drugs and therapy·2026
Same journal

Association of In-Hospital Dapagliflozin Initiation with Favorable left Ventricular Remodeling in Patients with Acute Myocardial Infarction and Heart Failure: A Retrospective Cohort Study.

Cardiovascular drugs and therapy·2026
Same journal

Impact of Nitric Oxide Metabolites On Early Perioperative Biochemical Changes and Postoperative Complications in High-BMI Patients Undergoing On-Pump CABG: an Exploratory Observational Cohort Study.

Cardiovascular drugs and therapy·2026
Same journal

Comparative Cardiovascular, Lipid, and Safety Effects of Lipid-Modifying Therapies in Diabetes: An Agent-, Class-, and Dose-Level Network Meta-Analysis.

Cardiovascular drugs and therapy·2026
Same journal

Cardiovascular Genetic Epidemiology in the Genome-Wide Era: From Association Discovery to Mechanistic Dissection and Clinical Translation.

Cardiovascular drugs and therapy·2026
See all related articles

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Nitrates are a cornerstone therapy for congestive heart failure (CHF).
  • They provide hemodynamic benefits by reducing cardiac workload and improving output.

Purpose of the Study:

  • To review the therapeutic effects and tolerance mechanisms of nitrates in CHF.
  • To provide guidance on optimal nitrate administration schedules for CHF patients.

Main Methods:

  • Review of existing literature on nitrate pharmacology and clinical use in CHF.
  • Analysis of hemodynamic effects, tolerance development, and clinical outcomes.

Main Results:

  • Nitrates decrease left ventricular filling pressure and systemic vascular resistance, improving cardiac function.

Related Experiment Videos

  • Tolerance to nitrates, particularly arterial tolerance, develops with continuous use due to reduced vascular smooth muscle sensitivity.
  • Nitrate therapy, especially in combination with hydralazine, shows benefits in mortality reduction and exercise tolerance.

    • Conclusions:

    • Nitrates are effective in acute pulmonary edema and severe refractory CHF.
    • A nightly nitrate-free interval is crucial for maintaining therapeutic efficacy during active hours due to tolerance development.