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[Malignant meningeal "histiocytosis"]

S Schröder1, J R Iglesias-Rozas, U Müller

  • 1Zentrum für Psychiatrie, Universitätsklinik Bochum, Deutschland.

Zentralblatt Fur Pathologie
|July 1, 1994
PubMed

Insights

Unusual meningeal tumors with histiocytic appearance were observed. Imaging and cerebrospinal fluid analysis initially misdiagnosed these as meningoencephalitis, highlighting diagnostic challenges.

Area of Science:

  • Neuropathology
  • Neuroimaging
  • Cytopathology

Background:

  • Meningeal tumors can present with diverse histological features.
  • Accurate diagnosis is crucial for appropriate patient management.

Observation:

  • Two cases of unusual pleomorphic meningeal tumors with histiocytic morphology are presented.
  • Computed tomography (CT) and magnetic resonance imaging (MRI) showed no parenchymal or meningeal lesions.
  • Cerebrospinal fluid (CSF) cytology revealed lymphocytic reaction but no tumor cells.

Findings:

  • Histological and immunohistological analysis identified tumor cells with histiocytic features.
  • Diagnostic challenges arose due to negative imaging and CSF cytology findings.
  • One patient exhibited psychiatric symptoms, complicating the clinical presentation.

Implications:

  • This case series underscores the importance of considering rare meningeal tumors despite non-specific initial findings.
  • Advanced imaging and comprehensive diagnostic approaches are essential for accurate diagnosis.
  • Understanding the histogenesis of these tumors may improve diagnostic strategies and patient outcomes.

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