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Capillary zone electrophoresis in pharmaceutical and biomedical analysis
Summary
Capillary zone electrophoresis is a versatile pharmaceutical analysis technique. It separates diverse compounds, including neutral and chiral molecules, with evolving methods.
Area of Science:
- Analytical Chemistry
- Separation Science
- Pharmaceutical Analysis
Background:
- Capillary zone electrophoresis (CZE) is increasingly adopted in the pharmaceutical industry.
- CZE is applicable to a broad spectrum of compounds, from small molecules to large biomolecules like nucleotides and proteins.
Purpose of the Study:
- To review the historical development and fundamental theory of CZE.
- To explain adaptations for separating neutral molecules and achieving chiral selectivity.
Main Methods:
- Review of historical data and theoretical principles of CZE.
- Analysis of adaptations for neutral molecule separation.
- Examination of methods for chiral selectivity in CZE.
Main Results:
- CZE demonstrates broad applicability for pharmaceutical compound analysis.
- Adaptations enable the separation of previously challenging neutral species.
- Methods for achieving chiral selectivity have been developed.
Conclusions:
- CZE is a powerful and evolving technique for pharmaceutical analysis.
- Its adaptability extends its utility to a wider range of molecules, including chiral compounds.