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Automated flow-injection technique for use in dissolution studies of sustained-release formulations: application to
C A Georgiou1, G N Valsami, P E Macheras
1Department of Chemistry, University of Athens, Panepistimiopolis, Kouponia, Greece.
Abstract:
The application of flow-injection analysis (FIA) to automated dissolution studies of sustained-release formulations is described. The long-term stability of the dissolution-FIA analyser was checked during unattended operation for 42 h. The construction of multiple calibration curves with the so-called electronic dilution FIA procedure was used to extend the linear range of the determination. The computer-controlled FIA system and the principles of associated software are described and applied to dissolution studies of sustained-release formulations of iron(II) using its sensitive reaction with the colour reagent, ferrozine. The extended linear range of the determination is 1-130 ppm iron(II) and the precision (RSD) better than 3% (n = 3).