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Positive nitrogen balance after intraperitoneal administration of amino acids in 3 patients
Objective:
To determine whether intraperitoneal (IP) administration of amino acids improves nitrogen balance during continuous ambulatory peritoneal dialysis (CAPD).
Design:
Nitrogen balance studies of CAPD patients comparing periods of peritoneal dialysis using dialysate with nitrogen added from a commercial amino acid solution, versus standard dialysate.
Setting:
Clinical research center in a tertiary facility.
Patients:
Patients on CAPD who volunteered.
Interventions:
One 4-day balance period was carried out with conventional dialysate and one 4-day period with conventional dialysate to which amino acids were added. The study periods were separated by a 3-day washout period.
Main Outcome Measures:
Nitrogen accumulation or loss during each period.
Results:
The mean (SD) daily control period balances (grams per day) were 0.2, 1.9, and -3.4; during the amino acid period the balances were 5.4, 2.7, -0.7. The mean daily control effluent dialysate volumes (milliliters) were 11,350 +/- 443, 10,052 +/- 449, and 10,165 +/- 154; during the amino acid period the volumes were 10,345 +/- 50, 12,325 +/- 1021, and 10,220 +/- 655.
Conclusions:
The IP addition of amino acids diminishes the amount of nitrogen lost from dialysate while maintaining effluent dialysate volume. Nitrogen balances improved in all 3 patients during the period with IP amino acids, compared to control.