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Related Experiment Videos

Stochastic versus deterministic variability in simple neuronal circuits: I. Monosynaptic spinal cord reflexes

T Chang1, S J Schiff, T Sauer

  • 1Department of Neurosurgery, Children's National Medical Center, Washington, D.C. 20010.

Biophysical Journal
|August 1, 1994
PubMed
Summary

Spinalization in cats eliminated oscillations in monosynaptic reflexes, suggesting a loss of deterministic neural control. This study reveals that the decerebrate state, unlike the spinalized state, exhibits deterministic reflex behavior.

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Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Motor Control

Background:

  • Monosynaptic reflexes are crucial for motor control.
  • The central nervous system's role in generating complex motor patterns is under investigation.
  • Understanding reflex variability can elucidate underlying neural mechanisms.

Purpose of the Study:

  • To investigate the presence of deterministic dynamics in monosynaptic Ia-afferent to alpha-motoneuron reflexes.
  • To determine the effect of spinalization on these reflex dynamics.
  • To differentiate between deterministic and stochastic behavior in neural reflexes.

Main Methods:

  • Recorded time series of monosynaptic reflexes in decerebrate and spinalized cats.
  • Utilized autocorrelation analysis to detect oscillations.

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  • Applied nonlinear time series analysis techniques (local flow, local dispersion, nonlinear prediction) to assess determinism.
  • Employed stochastic surrogate data for statistical controls.

    • Main Results:

    • Oscillations were observed in all reflexes from decerebrate cats but were absent after spinalization.
    • Evidence of deterministic structure was found in 2 out of 4 reflex time series from decerebrate cats.
    • This deterministic structure was abolished by spinalization and not explained by autocorrelation alone.
    • No evidence of determinism was found in any reflexes from spinalized cats.

    Conclusions:

    • Monosynaptic reflex activity in the decerebrate state can exhibit deterministic properties.
    • Spinalization disrupts the neural circuits responsible for this deterministic behavior.
    • Reflex variability, while often stochastic, can be influenced by higher brain centers, indicating potential for deterministic control.