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T lymphocyte function in patients with malignant biliary obstruction

S T Fan1, C M Lo, E C Lai

  • 1Department of Surgery, University of Hong Kong, Queen Mary Hospital.

Journal of Gastroenterology and Hepatology
|July 1, 1994
PubMed
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T lymphocyte function is impaired in patients with malignant biliary obstruction. Endoscopic drainage or surgery does not reverse this dysfunction, and worsening T cell function increases sepsis risk.

Area of Science:

  • Immunology
  • Gastroenterology
  • Oncology

Background:

  • Malignant biliary obstruction significantly impairs T lymphocyte function.
  • This dysfunction is more pronounced compared to gastric cancer patients and healthy individuals.

Purpose of the Study:

  • To evaluate the impact of pre-operative endoscopic drainage and surgery on T lymphocyte function in patients with malignant biliary obstruction.
  • To assess the correlation between T lymphocyte function and clinical parameters.
  • To determine the relationship between T lymphocyte function changes and postoperative sepsis incidence.

Main Methods:

  • Assessed T lymphocyte function using phytohaemagglutinin mitogen stimulation test.
  • Compared function in 59 patients with malignant biliary obstruction (pre- and post-intervention) against controls (gastric cancer patients and healthy individuals).

Related Experiment Videos

  • Utilized regression analysis to identify correlations with serum bilirubin, albumin, and transferrin levels.

    • Main Results:

    • T lymphocyte function was significantly impaired in patients with malignant biliary obstruction.
    • Impaired T lymphocyte function correlated negatively with serum bilirubin and positively with serum albumin and transferrin.
    • Neither endoscopic biliary drainage nor surgery substantially improved T lymphocyte function; postoperative deterioration was common.
    • Worsening T lymphocyte function was associated with a significantly higher incidence of postoperative sepsis.

    Conclusions:

    • Endoscopic biliary drainage and surgery do not reverse T lymphocyte dysfunction in malignant biliary obstruction.
    • T lymphocyte dysfunction is a significant risk factor for postoperative sepsis in these patients.