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P nucleotides, hairpin DNA and V(D)J joining: making the connection
1Division of Biology, California Institute of Technology, Pasadena 91125.
Seminars in Immunology
|June 1, 1994
Abstract:
The fine-structures of V(D)J joining products present a cache of information about the recombination process. Testable hypotheses with predictive value are beginning to provide a surprisingly detailed picture of the joining operation. Here, one feature of V(D)J junctions, the appearance of short palindromic inserts, is discussed, and experimental evidence in support of a joining model involving a hairpin-terminated DNA intermediate will be summarized.