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The mechanism of V(D)J recombination: site-specificity, reaction fidelity and immunologic diversity
M R Lieber1, C P Chang, M Gallo
1Department of Pathology, Stanford University School of Medicine, CA 94305-5324.
Seminars in Immunology
|June 1, 1994
Abstract:
Site-specific recombination reactions in higher eukaryotes are uncommon, perhaps because of the potential genomic instability that they may create. We focus this review on the issues of site-specificity, reaction fidelity and immunologic diversity in the V(D)J recombination reaction.